Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs

Therapeutic applications of nitric oxide releasing non steroidal anti- inflammatory drugs

This review examines the therapeutic potentials and mechanism of action of nitric oxide releasing non-steroidal anti-inflammatory drugs. NO-releasing NSAIDS markedly improve the anti-inflammatory and antinociceptive actions efficiently and diminish gastrointestinal toxicity. The nitric oxide releasing NSAIDS may be useful to treat wide variety of diseases like colitis, cancer, thrombosis, reste...

NO-NSAIDs. Part 3: nitric oxide-releasing prodrugs of non-steroidal anti-inflammatory drugs.

In continuation of our efforts to discover novel nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) as potentially "Safe NSAIDs," we report herein the design, synthesis and evaluation of 21 new NO-NSAIDs of commonly used NSAIDs such as aspirin, diclofenac, naproxen, flurbiprofen, ketoprofen, sulindac, ibuprofen and indomethacin. These prodrugs have NO-releasing disulfide l...

Nonsteroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...

Anti-fertility effect of non-steroidal anti-inflammatory drugs.

The anti-fertility activity of prostaglandin synthesis inhibitors namely the non-steroidal anti-inflammatory drugs: acetyl salicylic acid, indomethacin and oxyphenbutazone were investigated in male and female albino rats and female albino rabbits. Oxyphenbutazone and indomethacin affected the reproductive process in male rats. Indomethacin 3 mg/kg. and acetyl salicylic acid 300 mg/kg produced s...

Non-steroidal anti-inflammatory drugs.